CSF3

Across TCGA patient cohorts, CSF3 mutation is significantly associated with the total protein of many other genes, with 27 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CSF3-associated genes across cancer lineages are EGFR_pY1173, eIF4E, and A-Raf_pS299. Each is linked with CSF3 in more than 1 cancer types. Because this analysis shows association rather than direction, both CSF3-to-partner and partner-to-CSF3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1173 grouped by CSF3-low versus CSF3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CSF3→partner) and Y-score (partner→CSF3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1173 →	-0.146	-2.295	<.001	.036	3	1
UCEC	eIF4E →	+0.216	+2.820	.042	.035	3	1
UCEC	A-Raf_pS299 →	-0.269	-3.169	<.001	.019	3	1
UCEC	GATA6 →	-0.206	-2.314	.007	.035	3	1
UCEC	GSK-3a-b_pS21_S9 →	+0.616	+2.179	.004	.034	3	1
UCEC	Heregulin →	-0.243	-3.459	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 27 associations by consensus.

EGFR_pY1173 by CSF3 expression — UCEC

Explore this box plot interactively →