CSF2RB

Across TCGA patient cohorts, CSF2RB mutation is significantly associated with the total protein of many other genes, with 50 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CSF2RB-associated genes across cancer lineages are 4E-BP1, Cyclin-E2, and Cyclin-B1. Each is linked with CSF2RB in more than 3 cancer types. Because this analysis shows association rather than direction, both CSF2RB-to-partner and partner-to-CSF2RB results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 4E-BP1 grouped by CSF2RB-low versus CSF2RB-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CSF2RB→partner) and Y-score (partner→CSF2RB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	4E-BP1 →	+0.362	+2.837	<.001	.001	3	4
UCEC	Cyclin-E2 →	+0.166	+1.688	.004	.013	3	4
UCEC	Cyclin-B1 →	+0.759	+2.938	<.001	<.001	3	3
UCEC	GAPDH →	+0.412	+2.321	.026	.033	3	3
UCEC	C-Raf →	+0.196	+2.459	<.001	<.001	3	2
UCEC	ACC1 →	+0.373	+2.472	.003	.010	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 50 associations by consensus.

4E-BP1 by CSF2RB expression — UCEC

Explore this box plot interactively →