CSF1R

Across TCGA pan-cancer cohorts, CSF1R mass-spec protein differs between tumor and matched normal tissue in 7 of 18 cancer types tested, making tumor–normal expression one of CSF1R’s most consistent transcriptional readouts.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where CSF1R mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types CSF1R is over-expressed in tumor, although a few such as COAD and LUAD show the opposite, repressed pattern.

CCRCC, COAD, and LUAD are the cancer types where CSF1R tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CSF1R mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
CCRCC	Female	All	+1.017	<.001	11	view →
COAD	All	III,IV	−0.707	<.001	9	view →
LUAD	Male	II,III,IV	−0.417	<.001	9	view →
HNSC	All	III,IV	−0.408	<.001	8	view →
PDAC	All	All	+0.428	<.001	5	view →
LSCC	Male	All	−0.264	<.001	5	view →
OV	All	All	−0.976	<.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 7 strongest of 7 lineages.

CSF1R–CCRCC

Open the CCRCC breakdown →