CSF1R

Across TCGA patient cohorts, CSF1R mutation is significantly associated with the RNA expression of many other genes, with 2,752 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CSF1R-associated genes across cancer lineages are PATL1, REEP4, and MED9. Each is linked with CSF1R in more than 3 cancer types. Because this analysis shows association rather than direction, both CSF1R-to-partner and partner-to-CSF1R results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PATL1 grouped by CSF1R-low versus CSF1R-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CSF1R→partner) and Y-score (partner→CSF1R) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PATL1 →	+0.492	+2.818	<.001	.001	3	4
UCEC	REEP4 →	+0.517	+4.191	<.001	<.001	3	4
LUAD	MED9 →	+0.414	+2.700	<.001	.006	3	4
UCEC	RAD51C →	+0.368	+2.928	.002	<.001	3	4
UCEC	GPN3 →	+0.396	+2.354	.007	.003	3	4
SKCM	SDHB →	+0.437	+2.201	.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,752 associations by consensus.

PATL1 by CSF1R expression — UCEC

Explore this box plot interactively →