CSF1R

Across TCGA patient cohorts, CSF1R mutation is significantly associated with the total protein of many other genes, with 41 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CSF1R-associated genes across cancer lineages are eIF4E, 4E-BP1, and PCNA. Each is linked with CSF1R in more than 2 cancer types. Because this analysis shows association rather than direction, both CSF1R-to-partner and partner-to-CSF1R results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by CSF1R-low versus CSF1R-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CSF1R→partner) and Y-score (partner→CSF1R) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	eIF4E →	+0.114	+2.820	.040	.035	3	3
LUAD	4E-BP1 →	+0.302	+3.584	.027	.002	3	2
COAD	PCNA →	+0.327	+2.815	.016	.036	3	2
COAD	ASNS →	+0.798	+2.815	<.001	.036	3	2
UCEC	EGFR_pY1068 →	-0.197	-1.362	.026	.037	3	2
UCEC	ATM →	-0.406	-2.000	.011	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 41 associations by consensus.

eIF4E by CSF1R expression — LUAD

Explore this box plot interactively →