CSF1R

Across TCGA cell cohorts, CSF1R mutation is significantly associated with the RNA expression of many other genes, with 49 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible CSF1R-associated genes across cancer lineages are SSMEM1, DPRX, and CLLU1-AS1. Each is linked with CSF1R in more than 1 cancer types. Because this analysis shows association rather than direction, both CSF1R-to-partner and partner-to-CSF1R results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SSMEM1 grouped by CSF1R-low versus CSF1R-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CSF1R→partner) and Y-score (partner→CSF1R) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	SSMEM1 →	+0.028	+3.029	<.001	.006	3	2
LUNG_NSCLC_LUAD	DPRX →	+0.170	+4.228	<.001	<.001	3	2
OESOPHAGUS	CLLU1-AS1 →	+0.075	+4.392	<.001	.003	3	1
SOFT_TISSUE	OR4X2 →	+0.032	+5.369	<.001	.004	3	1
SOFT_TISSUE	PRR20B →	+0.043	+5.977	<.001	.001	3	1
SOFT_TISSUE	PRR20A →	+0.043	+5.977	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 49 associations by consensus.

SSMEM1 by CSF1R expression — LARGE_INTESTINE

Explore this box plot interactively →