Across TCGA patient cohorts, CSF1 mutation is significantly associated with the total protein of many other genes, with 25 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CSF1-associated genes across cancer lineages are Chk2_pT68, eEF2, and EGFR_pY1068. Each is linked with CSF1 in more than 1 cancer types. Because this analysis shows association rather than direction, both CSF1-to-partner and partner-to-CSF1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CSF1→partner) and Y-score (partner→CSF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Chk2_pT68 →	-0.183	-2.990	.006	<.001	3	2
UCEC	eEF2 →	+0.291	+2.459	.023	.019	3	1
UCEC	EGFR_pY1068 →	-0.253	-3.584	.005	.002	3	1
UCEC	eIF4E →	+0.176	+2.807	.020	.003	3	1
UCEC	A-Raf_pS299 →	-0.099	-2.321	.021	.033	3	1
UCEC	JNK2 →	+0.234	+2.348	.001	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 25 associations by consensus.

Exploration

CSF1 survival (RNA) · tumor vs normal (RNA) · all CSF1 data types