CSE1L

Across TCGA patient cohorts, CSE1L mutation is significantly associated with the total protein of many other genes, with 34 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CSE1L-associated genes across cancer lineages are eIF4E, MEK1, and MSH2. Each is linked with CSE1L in more than 1 cancer types. Because this analysis shows association rather than direction, both CSE1L-to-partner and partner-to-CSE1L results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by CSE1L-low versus CSE1L-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CSE1L→partner) and Y-score (partner→CSE1L) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.154	+1.584	.029	.009	3	2
UCEC	MEK1 →	+0.340	+2.201	.005	<.001	3	2
UCEC	MSH2 →	-0.224	-1.781	.003	.024	3	2
UCEC	PCNA →	+0.251	+2.201	<.001	<.001	3	2
UCEC	TFRC →	+0.434	+1.874	.014	.049	3	2
UCEC	VHL →	-0.796	-1.662	<.001	.010	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 34 associations by consensus.

eIF4E by CSE1L expression — UCEC

Explore this box plot interactively →