CSDE1

Across TCGA patient cohorts, CSDE1 mutation is significantly associated with the total protein of many other genes, with 51 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CSDE1-associated genes across cancer lineages are ATM, 4E-BP1, and Cyclin-B1. Each is linked with CSDE1 in more than 2 cancer types. Because this analysis shows association rather than direction, both CSDE1-to-partner and partner-to-CSDE1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by CSDE1-low versus CSDE1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CSDE1→partner) and Y-score (partner→CSDE1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.649	-1.628	<.001	<.001	3	3
UCEC	4E-BP1 →	+0.330	+1.999	<.001	<.001	3	3
COAD	Cyclin-B1 →	+0.880	+2.815	.003	.036	3	2
UCEC	eIF4E →	+0.163	+1.807	.004	<.001	3	2
UCEC	PCNA →	+0.209	+2.392	<.001	<.001	3	2
UCEC	TFRC →	+0.326	+1.280	.023	.049	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 51 associations by consensus.

ATM by CSDE1 expression — UCEC

Explore this box plot interactively →