CS

Across TCGA pan-cancer cohorts, CS mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated CS data layer compared with 28 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher CS mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated CS expression acts as an unfavorable survival marker, although some lineages such as LSCC and GBM show a favorable association.

LSCC, PDAC, and CCRCC are the cancer types where CS mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	DFS	Tertile	II,III,IV	1.000	0.831	.007	17	view →
PDAC	OS	Quartile	III,IV	0.351	1.000	.004	14	view →
CCRCC	DFS	Quartile	III,IV	0.424	0.761	.029	8	view →
HNSC	OS	Median	III,IV	0.780	0.915	.020	8	view →
LUAD	DFS	Median	All	0.520	0.745	.016	4	view →
GBM	OS	Quartile	All	0.885	0.709	.013	4	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

CS–LSCC (DFS)

Open the LSCC breakdown →