CS

RNA expression — cross-omics
Cross-omicsRNA → PROTEIN-MSPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, CS RNA expression is significantly associated with the protein abundance of many other proteins, with 17,550 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible CS-associated proteins across cancer lineages are PTGES3, SMARCA4, and SNRPD2. Each is linked with CS in more than 5 cancer types. Because this analysis shows association rather than direction, both CS-to-partner and partner-to-CS results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, CS versus PTGES3 in LSCC, with a Pearson correlation of 0.62.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (CS→partner) and Y-score (partner→CS) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.
LineagePartner proteinX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
LSCCPTGES3 →+0.311+0.571<.001<.00136
LSCCSMARCA4 →+0.356+0.369<.001<.00136
GBMSNRPD2 →+0.214+0.209.005.00936
HNSCC1orf35 →+0.446+0.783<.001<.00136
LSCCCDK9 →+0.317+0.519<.001<.00136
LSCCUSP39 →+0.364+0.508<.001<.00135
Each partner links to its Q-omics profile. Showing the 6 strongest of 17,550 associations by consensus.

CS vs PTGES3 — LSCC

Per-sample scatter of CS vs PTGES3 in LSCC (Pearson r = 0.62).

Explore this scatter interactively →

Exploration