CS

Across TCGA patient cohorts, CS mutation is significantly associated with the total protein of many other genes, with 14 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CS-associated genes across cancer lineages are eIF4E, Acetyl-a-Tubulin-Lys40, and IGFBP2. Each is linked with CS in more than 1 cancer types. Because this analysis shows association rather than direction, both CS-to-partner and partner-to-CS results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by CS-low versus CS-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CS→partner) and Y-score (partner→CS) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.261	+3.807	.006	<.001	3	1
UCEC	Acetyl-a-Tubulin-Lys40 →	+0.480	+2.000	.036	.032	3	1
UCEC	IGFBP2 →	-0.805	-3.321	.005	.010	3	1
UCEC	JNK2 →	+0.197	+2.000	.028	.032	3	1
UCEC	p70-S6K →	+0.209	+2.026	.016	.018	3	1
UCEC	PCNA →	+0.205	+2.999	.035	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

eIF4E by CS expression — UCEC

Explore this box plot interactively →