CS

Across TCGA cell cohorts, CS mutation is significantly associated with the drug of many other genes, with 16 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CS-associated genes across cancer lineages are Niraparib, LCL161, and Leflunomide. Each is linked with CS in more than 1 cancer types. Because this analysis shows association rather than direction, both CS-to-partner and partner-to-CS results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Niraparib grouped by CS-low versus CS-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CS→partner) and Y-score (partner→CS) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	Niraparib →	+0.459	+2.678	.009	.037	3	1
LARGE_INTESTINE	LCL161 →	+0.340	+2.646	.037	.047	3	1
LARGE_INTESTINE	Leflunomide →	+0.294	+2.769	.021	.040	3	1
LARGE_INTESTINE	50869 →	+0.431	+2.649	.041	.046	3	1
LARGE_INTESTINE	150412 →	+0.469	+2.777	.004	.038	3	1
LARGE_INTESTINE	BDF00022089a →	+0.337	+2.649	.030	.046	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

Niraparib by CS expression — LARGE_INTESTINE

Explore this box plot interactively →