Across TCGA pan-cancer cohorts, CRYZL1 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated CRYZL1 data layer compared with 22 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher CRYZL1 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated CRYZL1 expression acts as an unfavorable survival marker, although some lineages such as PDAC and CCRCC show a favorable association.

UCEC, PDAC, and CCRCC are the cancer types where CRYZL1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	OS	Median	II,III,IV	0.522	1.000	.003	40	view →
PDAC	DFS	Tertile	All	0.918	0.669	.006	20	view →
CCRCC	DFS	Tertile	II,III,IV	0.928	0.105	.006	13	view →
HNSC	OS	Median	All	1.000	0.484	.038	12	view →
LSCC	DFS	Quartile	II,III,IV	0.921	0.229	.024	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

Exploration

Same gene, other analysis: CRYZL1 tumor-vs-normal RNA expression · all CRYZL1 data types