Across TCGA patient cohorts, CRYZL1 mutation is significantly associated with the total protein of many other genes, with 18 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CRYZL1-associated genes across cancer lineages are TIGAR, ATM, and Ku80. Each is linked with CRYZL1 in more than 2 cancer types. Because this analysis shows association rather than direction, both CRYZL1-to-partner and partner-to-CRYZL1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CRYZL1→partner) and Y-score (partner→CRYZL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TIGAR →	+0.168	+2.348	.028	.019	3	3
UCEC	ATM →	-0.773	-2.321	<.001	.035	3	2
UCEC	Ku80 →	+0.372	+3.013	.001	.018	3	1
UCEC	MEK1 →	+0.588	+3.459	.001	.005	3	1
UCEC	p62 Lck ligand →	+0.395	+2.321	.015	.035	3	1
UCEC	p90 RSK_pT359_S363 →	-0.227	-2.321	.025	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 18 associations by consensus.

Exploration

CRYZL1 survival (RNA) · tumor vs normal (RNA) · all CRYZL1 data types