CRYL1

Across TCGA patient cohorts, CRYL1 mutation is significantly associated with the total protein of many other genes, with 23 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CRYL1-associated genes across cancer lineages are FOXO3a_pS318_S321, JNK2, and Ku80. Each is linked with CRYL1 in more than 1 cancer types. Because this analysis shows association rather than direction, both CRYL1-to-partner and partner-to-CRYL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FOXO3a_pS318_S321 grouped by CRYL1-low versus CRYL1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CRYL1→partner) and Y-score (partner→CRYL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FOXO3a_pS318_S321 →	-0.149	-3.160	.017	.019	3	1
UCEC	JNK2 →	+0.330	+3.009	<.001	.019	3	1
UCEC	Ku80 →	+0.379	+3.472	.001	.002	3	1
UCEC	Notch1 →	+0.234	+3.459	<.001	.005	3	1
UCEC	PI3K-p85 →	-0.322	-2.990	.002	.036	3	1
UCEC	PKC-b-II_pS660 →	-0.463	-3.321	<.001	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 23 associations by consensus.

FOXO3a_pS318_S321 by CRYL1 expression — UCEC

Explore this box plot interactively →