Across TCGA pan-cancer cohorts, CRYGS Mutation is linked to patient survival in 3 of 34 cancer types, making it a survival-associated CRYGS data layer compared with 23 for mass-spec protein and 1 for mass-spec protein.

The strongest signal is observed in sarcoma (SARC), where higher CRYGS Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated CRYGS expression acts as an unfavorable survival marker.

SARC, UCEC, and PRAD are the cancer types where CRYGS Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SARC	DFS	Median	All	0.094	0.611	.001	9	view →
UCEC	OS	Median	IV	0.231	0.592	.036	6	view →
PRAD	DFS	Median	All	0.085	0.774	<.001	6	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

Exploration

Same gene, other analysis: CRYGS tumor-vs-normal RNA expression · all CRYGS data types