Across TCGA patient cohorts, CRYGS mutation is significantly associated with the total protein of many other genes, with 16 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CRYGS-associated genes across cancer lineages are eEF2, eIF4E, and A-Raf_pS299. Each is linked with CRYGS in more than 1 cancer types. Because this analysis shows association rather than direction, both CRYGS-to-partner and partner-to-CRYGS results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CRYGS→partner) and Y-score (partner→CRYGS) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eEF2 →	+0.413	+3.169	.013	.018	3	1
UCEC	eIF4E →	+0.219	+3.700	.026	.001	2	2
UCEC	A-Raf_pS299 →	-0.170	-3.169	.002	.019	3	1
UCEC	p70-S6K_pT389 →	-0.186	-2.999	.036	.035	3	1
UCEC	PDCD4 →	-0.559	-2.584	.010	.011	3	1
UCEC	Shc_pY317 →	-0.239	-3.169	<.001	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

Exploration

CRYGS survival (RNA) · tumor vs normal (RNA) · all CRYGS data types