CRYGN

Across TCGA patient cohorts, CRYGN mutation is significantly associated with the RNA expression of many other genes, with 444 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible CRYGN-associated genes across cancer lineages are PLRG1, MTND2P30, and RPL35AP3. Each is linked with CRYGN in more than 1 cancer types. Because this analysis shows association rather than direction, both CRYGN-to-partner and partner-to-CRYGN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PLRG1 grouped by CRYGN-low versus CRYGN-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CRYGN→partner) and Y-score (partner→CRYGN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	PLRG1 →	+0.516	+3.328	.007	.005	3	2
SKCM	MTND2P30 →	+0.058	+3.098	<.001	.008	3	2
SKCM	RPL35AP3 →	+0.317	+3.027	<.001	.001	3	2
SKCM	RPS29P28 →	+0.095	+4.315	<.001	.005	3	2
LUAD	CA15P2 →	+0.071	+4.481	<.001	.009	3	2
UCEC	MIR3154 →	+0.145	+4.566	<.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 444 associations by consensus.

PLRG1 by CRYGN expression — SKCM

Explore this box plot interactively →