CRYGN

Across TCGA patient cohorts, CRYGN mutation is significantly associated with the total protein of many other genes, with 7 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CRYGN-associated genes across cancer lineages are eIF4E, JNK_pT183_Y185, and Lck. Each is linked with CRYGN in more than 1 cancer types. Because this analysis shows association rather than direction, both CRYGN-to-partner and partner-to-CRYGN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by CRYGN-low versus CRYGN-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CRYGN→partner) and Y-score (partner→CRYGN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.257	+3.169	.020	.019	3	1
UCEC	JNK_pT183_Y185 →	-0.198	-3.000	.025	.036	3	1
UCEC	Lck →	+0.304	+3.321	.003	.010	3	1
SKCM	Smac →	+0.324	+2.824	.048	.036	3	1
UCEC	p90 RSK →	+0.206	+2.183	.039	.035	2	1
UCEC	Caspase-7-cleavedD198 →	+0.841	+2.827	.006	.035	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

eIF4E by CRYGN expression — UCEC

Explore this box plot interactively →