Across TCGA pan-cancer cohorts, CRYGEP RNA differs between tumor and matched normal tissue in 1 of 18 cancer types tested, making tumor–normal expression one of CRYGEP’s most consistent transcriptional readouts.
The strongest signal is observed in prostate adenocarcinoma (PRAD), where CRYGEP RNA is repressed in tumor relative to normal tissue. In most cancer types CRYGEP is over-expressed in tumor, although a few such as PRAD show the opposite, repressed pattern.
PRAD are the cancer types where CRYGEP tumor–normal differential expression is most reproducible.