CRYGD

Across TCGA pan-cancer cohorts, CRYGD RNA differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of CRYGD’s most consistent transcriptional readouts.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where CRYGD RNA is repressed in tumor relative to normal tissue. In most cancer types CRYGD is over-expressed in tumor, although a few such as BLCA and BRCA show the opposite, repressed pattern.

BLCA, BRCA, and UCEC are the cancer types where CRYGD tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CRYGD RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
BLCA	All	All	−0.312	.003	7	view →
BRCA	All	II,III,IV	−0.023	<.001	6	view →
UCEC	All	All	−0.819	.017	4	view →
PRAD	All	All	−0.568	<.001	2	view →
COAD	All	All	−0.044	.028	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

CRYGD–BLCA

Open the BLCA breakdown →