CRYGB

Across TCGA patient cohorts, CRYGB mutation is significantly associated with the RNA expression of many other genes, with 824 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CRYGB-associated genes across cancer lineages are HMX3, TOMM22P5, and RN7SL173P. Each is linked with CRYGB in more than 1 cancer types. Because this analysis shows association rather than direction, both CRYGB-to-partner and partner-to-CRYGB results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HMX3 grouped by CRYGB-low versus CRYGB-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CRYGB→partner) and Y-score (partner→CRYGB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	HMX3 →	+1.131	+2.345	<.001	.008	3	2
UCEC	TOMM22P5 →	+0.308	+3.897	<.001	<.001	3	2
SKCM	RN7SL173P →	+0.117	+3.508	.005	.006	3	2
LUSC	LINC02719 →	+0.156	+5.404	.008	.005	3	2
LUSC	OR52L2P →	+0.131	+5.093	<.001	.008	3	2
LUSC	MIR4798 →	+0.605	+6.733	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 824 associations by consensus.

HMX3 by CRYGB expression — UCEC

Explore this box plot interactively →