CRYGB

Across TCGA patient cohorts, CRYGB mutation is significantly associated with the total protein of many other genes, with 13 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CRYGB-associated genes across cancer lineages are Bax, C-Raf, and INPP4B. Each is linked with CRYGB in more than 1 cancer types. Because this analysis shows association rather than direction, both CRYGB-to-partner and partner-to-CRYGB results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Bax grouped by CRYGB-low versus CRYGB-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CRYGB→partner) and Y-score (partner→CRYGB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Bax →	+0.362	+3.169	.005	.020	3	2
UCEC	C-Raf →	+0.167	+3.000	.034	.036	3	1
UCEC	INPP4B →	-0.401	-3.156	.023	.020	2	1
UCEC	PDCD4 →	-0.933	-3.169	<.001	.020	2	1
UCEC	Shc_pY317 →	-0.202	-3.169	.015	.020	1	2
UCEC	ATM →	-0.650	-3.169	.008	.020	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 13 associations by consensus.

Bax by CRYGB expression — UCEC

Explore this box plot interactively →