CRYGA

Across TCGA patient cohorts, CRYGA mutation is significantly associated with the RNA expression of many other genes, with 724 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CRYGA-associated genes across cancer lineages are MTCYBP36, INCENP, and CCDC15. Each is linked with CRYGA in more than 1 cancer types. Because this analysis shows association rather than direction, both CRYGA-to-partner and partner-to-CRYGA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MTCYBP36 grouped by CRYGA-low versus CRYGA-high in STAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CRYGA→partner) and Y-score (partner→CRYGA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	MTCYBP36 →	+0.325	+3.912	<.001	.004	3	2
UCEC	INCENP →	+0.799	+2.627	.002	.006	3	1
UCEC	CCDC15 →	+0.551	+3.338	<.001	.005	3	1
UCEC	VPS26B →	+0.566	+3.721	<.001	<.001	3	1
UCEC	SLC25A4 →	+0.618	+3.711	.002	<.001	3	1
UCEC	GUF1 →	+0.579	+2.595	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 724 associations by consensus.

MTCYBP36 by CRYGA expression — STAD

Explore this box plot interactively →