CRYGA

Across TCGA patient cohorts, CRYGA mutation is significantly associated with the total protein of many other genes, with 10 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CRYGA-associated genes across cancer lineages are Shc_pY317, MEK1, and p62 Lck ligand. Each is linked with CRYGA in more than 1 cancer types. Because this analysis shows association rather than direction, both CRYGA-to-partner and partner-to-CRYGA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Shc_pY317 grouped by CRYGA-low versus CRYGA-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CRYGA→partner) and Y-score (partner→CRYGA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Shc_pY317 →	-0.186	-2.321	.014	.035	3	2
UCEC	MEK1 →	+0.477	+3.459	.009	.005	3	1
UCEC	p62 Lck ligand →	+0.472	+3.169	.003	.018	3	1
UCEC	Rab25 →	-0.499	-3.169	.002	.019	3	1
UCEC	VHL →	-1.076	-3.321	.001	.010	3	1
UCEC	Caspase-8 →	-0.300	-2.973	.017	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

Shc_pY317 by CRYGA expression — UCEC

Explore this box plot interactively →