CRYBG3

Across TCGA patient cohorts, CRYBG3 mutation is significantly associated with the RNA expression of many other genes, with 6,394 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CRYBG3-associated genes across cancer lineages are DDIT3, BCAS2, and IL7. Each is linked with CRYBG3 in more than 3 cancer types. Because this analysis shows association rather than direction, both CRYBG3-to-partner and partner-to-CRYBG3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DDIT3 grouped by CRYBG3-low versus CRYBG3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CRYBG3→partner) and Y-score (partner→CRYBG3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	DDIT3 →	+0.490	+1.606	<.001	<.001	3	4
UCEC	BCAS2 →	+0.439	+2.273	<.001	<.001	3	4
COAD	IL7 →	+0.576	+3.200	.007	.009	3	3
COAD	CCL8 →	+1.084	+2.807	<.001	.003	3	3
COAD	ITGB1BP1 →	+0.337	+3.200	.002	.009	3	3
COAD	COPS3 →	+0.588	+3.331	<.001	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,394 associations by consensus.

DDIT3 by CRYBG3 expression — UCEC

Explore this box plot interactively →