CRYBG3

Across TCGA patient cohorts, CRYBG3 mutation is significantly associated with the total protein of many other genes, with 60 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CRYBG3-associated genes across cancer lineages are 14-3-3_beta, Ku80, and Di-Ras3. Each is linked with CRYBG3 in more than 2 cancer types. Because this analysis shows association rather than direction, both CRYBG3-to-partner and partner-to-CRYBG3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 14-3-3_beta grouped by CRYBG3-low versus CRYBG3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CRYBG3→partner) and Y-score (partner→CRYBG3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	14-3-3_beta →	-0.064	-1.880	.022	.014	3	3
UCEC	Ku80 →	+0.222	+1.508	<.001	.001	3	3
UCEC	Di-Ras3 →	-0.147	-3.156	<.001	<.001	3	3
BRCA	PI3K-p85 →	+0.320	+2.812	.013	.037	3	2
UCEC	eIF4E →	+0.193	+2.515	<.001	<.001	3	2
UCEC	A-Raf_pS299 →	-0.105	-1.459	.001	.011	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 60 associations by consensus.

14-3-3_beta by CRYBG3 expression — UCEC

Explore this box plot interactively →