CRYBG3

Across TCGA cell cohorts, CRYBG3 mutation is significantly associated with the RNA expression of many other genes, with 1,813 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CRYBG3-associated genes across cancer lineages are SH3BGR, AP3S2, and GOT1. Each is linked with CRYBG3 in more than 2 cancer types. Because this analysis shows association rather than direction, both CRYBG3-to-partner and partner-to-CRYBG3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SH3BGR grouped by CRYBG3-low versus CRYBG3-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CRYBG3→partner) and Y-score (partner→CRYBG3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	SH3BGR →	+0.686	+2.700	<.001	<.001	3	3
LUNG_NSCLC_LUAD	AP3S2 →	+0.476	+2.621	.006	.003	3	3
LARGE_INTESTINE	GOT1 →	+0.631	+2.584	<.001	.002	3	3
LARGE_INTESTINE	THUMPD3 →	+0.395	+2.043	.002	.001	3	3
LARGE_INTESTINE	KMT5A →	+0.673	+2.043	<.001	.001	3	3
LARGE_INTESTINE	PKN2 →	+0.628	+2.545	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,813 associations by consensus.

SH3BGR by CRYBG3 expression — LARGE_INTESTINE

Explore this box plot interactively →