CRYBG2

Across TCGA patient cohorts, CRYBG2 mutation is significantly associated with the RNA expression of many other genes, with 3,170 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CRYBG2-associated genes across cancer lineages are RNASEH1, DNAJC9, and CWF19L1. Each is linked with CRYBG2 in more than 2 cancer types. Because this analysis shows association rather than direction, both CRYBG2-to-partner and partner-to-CRYBG2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNASEH1 grouped by CRYBG2-low versus CRYBG2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CRYBG2→partner) and Y-score (partner→CRYBG2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNASEH1 →	+0.515	+2.534	<.001	<.001	3	3
SKCM	DNAJC9 →	+0.512	+1.970	<.001	.002	3	3
SKCM	CWF19L1 →	+0.372	+3.018	.001	<.001	3	3
UCEC	RPL23AP82 →	+0.421	+3.010	<.001	<.001	3	3
UCEC	CIDECP1 →	+0.355	+2.191	<.001	<.001	3	3
UCEC	PGAM5 →	+0.606	+3.906	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,170 associations by consensus.

RNASEH1 by CRYBG2 expression — UCEC

Explore this box plot interactively →