CRYBG2

Across TCGA patient cohorts, CRYBG2 mutation is significantly associated with the total protein of many other genes, with 47 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CRYBG2-associated genes across cancer lineages are p90 RSK, p62 Lck ligand, and ASNS. Each is linked with CRYBG2 in more than 2 cancer types. Because this analysis shows association rather than direction, both CRYBG2-to-partner and partner-to-CRYBG2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p90 RSK grouped by CRYBG2-low versus CRYBG2-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CRYBG2→partner) and Y-score (partner→CRYBG2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	p90 RSK →	-0.278	-3.313	.024	.010	3	2
UCEC	p62 Lck ligand →	+0.506	+2.736	<.001	<.001	3	2
UCEC	ASNS →	+0.457	+1.906	<.001	.015	3	2
UCEC	CDK1 →	+0.114	+2.335	.039	.018	3	2
UCEC	Cyclin-E2 →	+0.130	+1.502	.036	.030	3	2
LUAD	p21 →	+0.490	+3.169	.008	.019	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 47 associations by consensus.

p90 RSK by CRYBG2 expression — COAD

Explore this box plot interactively →