CRYBG1

Across TCGA pan-cancer cohorts, CRYBG1 mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated CRYBG1 data layer compared with 24 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher CRYBG1 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated CRYBG1 expression acts as an unfavorable survival marker, although some lineages such as UCEC and COAD show a favorable association.

UCEC, PDAC, and COAD are the cancer types where CRYBG1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Median	III,IV	1.000	0.421	.006	38	view →
PDAC	OS	Quartile	All	0.290	0.614	.002	34	view →
COAD	DFS	Median	All	1.000	0.891	.026	12	view →
LSCC	OS	Tertile	All	0.840	0.977	.010	7	view →
LUAD	OS	Tertile	All	0.557	0.913	.006	6	view →
CCRCC	OS	Quartile	All	0.770	0.919	.032	4	view →
HNSC	OS	Median	All	0.900	0.791	.020	3	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

CRYBG1–UCEC (DFS)

Open the UCEC breakdown →