CRYBG1

Across TCGA cell cohorts, CRYBG1 mutation is significantly associated with the RNA expression of many other genes, with 147 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CRYBG1-associated genes across cancer lineages are FCGR3B, SCYGR10, and CELA2B. Each is linked with CRYBG1 in more than 1 cancer types. Because this analysis shows association rather than direction, both CRYBG1-to-partner and partner-to-CRYBG1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FCGR3B grouped by CRYBG1-low versus CRYBG1-high in LIVER.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CRYBG1→partner) and Y-score (partner→CRYBG1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	FCGR3B →	+0.021	+2.874	<.001	.008	3	2
OESOPHAGUS	SCYGR10 →	+0.203	+4.906	<.001	.006	3	2
LARGE_INTESTINE	CELA2B →	+0.033	+2.425	.001	.004	3	2
LARGE_INTESTINE	F11 →	+0.034	+2.619	<.001	.002	3	2
OVARY	RBMY1A1 →	+0.143	+5.807	<.001	.001	3	2
CNS	SLC2A7 →	+0.014	+3.887	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 147 associations by consensus.

FCGR3B by CRYBG1 expression — LIVER

Explore this box plot interactively →