CRYBB2P1

Across TCGA pan-cancer cohorts, CRYBB2P1 RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of CRYBB2P1’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where CRYBB2P1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types CRYBB2P1 is over-expressed in tumor.

HNSC, KIRC, and BLCA are the cancer types where CRYBB2P1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CRYBB2P1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	IV	+0.870	<.001	11	view →
KIRC	Female	All	+0.668	<.001	11	view →
BLCA	All	All	+0.731	<.001	9	view →
LIHC	Female	II,III,IV	+0.963	<.001	7	view →
LUSC	All	All	+0.392	<.001	6	view →
CHOL	Male	All	+2.095	<.001	5	view →
COAD	Female	All	+0.672	<.001	5	view →
STAD	All	II,III,IV	+0.599	<.001	4	view →
UCEC	All	All	+0.484	.013	4	view →
READ	Female	All	+0.629	<.001	2	view →
ESCA	All	All	+0.402	.005	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

CRYBB2P1–HNSC

Open the HNSC breakdown →