CRYBB2

Across TCGA patient cohorts, CRYBB2 mutation is significantly associated with the total protein of many other genes, with 9 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CRYBB2-associated genes across cancer lineages are HER3, MSH2, and Bim. Each is linked with CRYBB2 in more than 1 cancer types. Because this analysis shows association rather than direction, both CRYBB2-to-partner and partner-to-CRYBB2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HER3 grouped by CRYBB2-low versus CRYBB2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CRYBB2→partner) and Y-score (partner→CRYBB2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	HER3 →	-0.362	-2.986	.022	.037	3	1
UCEC	MSH2 →	-0.324	-3.000	.015	.037	3	1
UCEC	Bim →	-0.300	-3.000	.048	.037	3	1
UCEC	DJ-1 →	+0.233	+3.000	.015	.037	3	1
SKCM	ETS-1 →	-0.310	-3.169	.040	.019	3	1
UCEC	14-3-3_zeta →	+0.240	+3.026	.044	.019	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

HER3 by CRYBB2 expression — UCEC

Explore this box plot interactively →