CRYBB1

Across TCGA pan-cancer cohorts, CRYBB1 mass-spec protein differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of CRYBB1’s most consistent transcriptional readouts.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where CRYBB1 mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types CRYBB1 is over-expressed in tumor, although a few such as LSCC and LUAD show the opposite, repressed pattern.

LSCC, CCRCC, and LUAD are the cancer types where CRYBB1 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CRYBB1 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LSCC	Male	All	−0.276	<.001	6	view →
CCRCC	All	All	+0.579	<.001	5	view →
LUAD	Female	III,IV	−0.498	.001	5	view →
HNSC	Male	All	−0.475	.033	2	view →
PDAC	All	IV	−0.833	.032	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

CRYBB1–LSCC

Open the LSCC breakdown →