CRYBB1

Across TCGA patient cohorts, CRYBB1 mutation is significantly associated with the total protein of many other genes, with 11 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CRYBB1-associated genes across cancer lineages are PKC-delta_pS664, EGFR, and mTOR_pS2448. Each is linked with CRYBB1 in more than 1 cancer types. Because this analysis shows association rather than direction, both CRYBB1-to-partner and partner-to-CRYBB1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PKC-delta_pS664 grouped by CRYBB1-low versus CRYBB1-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CRYBB1→partner) and Y-score (partner→CRYBB1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	PKC-delta_pS664 →	-0.245	-2.321	.008	.035	3	2
UCEC	EGFR →	-0.282	-3.169	.001	.020	3	1
UCEC	mTOR_pS2448 →	-0.203	-2.980	.013	.036	3	1
UCEC	PCNA →	+0.406	+3.169	<.001	.020	3	1
UCEC	PDCD4 →	-0.656	-3.169	.011	.020	3	1
UCEC	Rictor_pT1135 →	-0.120	-3.169	.033	.020	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

PKC-delta_pS664 by CRYBB1 expression — SKCM

Explore this box plot interactively →