CRYBB1

Across TCGA cell cohorts, CRYBB1 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,128 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible CRYBB1-associated GO terms across cancer lineages are Endosomal lumen acidification, Carbohydrate derivative catabolic process, and Positive regulation of matrix metallopeptidase secretion. Each is linked with CRYBB1 in more than 3 cancer types. Because this analysis shows association rather than direction, both CRYBB1-to-partner and partner-to-CRYBB1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Endosomal lumen acidification grouped by CRYBB1-low versus CRYBB1-high in LUNG_SCLC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CRYBB1→partner) and Y-score (partner→CRYBB1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	Endosomal lumen acidification →	+0.079	+0.465	.002	.009	3	4
LUNG_SCLC	Carbohydrate derivative catabolic process →	-0.061	-0.622	.001	<.001	3	3
BLOOD_Leukemia	Positive regulation of matrix metallopeptidase secretion →	-0.132	-0.613	.007	.003	3	3
BLOOD_Lymphoma	Regulation of smooth muscle cell-matrix adhesion →	-0.737	-0.266	<.001	.001	3	3
BLOOD_Leukemia	Response to molecule of fungal origin →	+0.950	+0.690	<.001	<.001	3	3
BLOOD_Lymphoma	Positive regulation of cell growth →	+0.026	+0.206	.001	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,128 associations by consensus.

Endosomal lumen acidification by CRYBB1 expression — LUNG_SCLC

Explore this box plot interactively →