CRYBA1

Across TCGA patient cohorts, CRYBA1 mutation is significantly associated with the RNA expression of many other genes, with 242 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CRYBA1-associated genes across cancer lineages are RN7SKP86, RNA5SP503, and WHAMM. Each is linked with CRYBA1 in more than 1 cancer types. Because this analysis shows association rather than direction, both CRYBA1-to-partner and partner-to-CRYBA1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RN7SKP86 grouped by CRYBA1-low versus CRYBA1-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CRYBA1→partner) and Y-score (partner→CRYBA1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	RN7SKP86 →	+0.128	+6.199	<.001	.001	3	2
UCEC	RNA5SP503 →	+0.231	+3.036	.001	.009	3	2
UCEC	WHAMM →	+0.691	+3.386	<.001	.004	3	1
UCEC	TRAT1 →	+0.467	+3.353	.007	.005	3	1
UCEC	COX18 →	+0.543	+3.459	.003	.005	3	1
UCEC	METTL2B →	+0.517	+3.480	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 242 associations by consensus.

RN7SKP86 by CRYBA1 expression — SKCM

Explore this box plot interactively →