CRY1

Across TCGA cell cohorts, CRY1 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,097 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible CRY1-associated GO terms across cancer lineages are Centriole replication, Regulation of hippo signaling, and Negative regulation of hippo signaling. Each is linked with CRY1 in more than 13 cancer types. Because this analysis shows association rather than direction, both CRY1-to-partner and partner-to-CRY1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Centriole replication grouped by CRY1-low versus CRY1-high in LARGE_INTESTINE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CRY1→partner) and Y-score (partner→CRY1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	Centriole replication →	+0.104	+1.023	<.001	<.001	3	13
LIVER	Regulation of hippo signaling →	+0.099	+0.819	.006	.005	2	14
LIVER	Negative regulation of hippo signaling →	+0.106	+0.958	.003	<.001	3	13
LUNG_NSCLC_LUSC	Positive regulation of gluconeogenesis →	+0.127	+0.961	.001	<.001	3	13
LARGE_INTESTINE	Positive regulation of organelle assembly →	+0.058	+0.896	<.001	<.001	3	12
SOFT_TISSUE	Regulation of centrosome cycle →	+0.069	+1.209	.001	<.001	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,097 associations by consensus.

Centriole replication by CRY1 expression — LARGE_INTESTINE

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