CRY1

Across TCGA cell cohorts, CRY1 mutation is significantly associated with the RNA expression of many other genes, with 17 significant associations in total. LUNG_SCLC shows the largest number of these associations.

The most reproducible CRY1-associated genes across cancer lineages are IFNA14, OR4F4, and OR4F5. Each is linked with CRY1 in more than 1 cancer types. Because this analysis shows association rather than direction, both CRY1-to-partner and partner-to-CRY1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IFNA14 grouped by CRY1-low versus CRY1-high in CNS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CRY1→partner) and Y-score (partner→CRY1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	IFNA14 →	+0.116	+6.357	<.001	<.001	3	2
LUNG_SCLC	OR4F4 →	+0.016	+5.643	<.001	.002	3	1
LUNG_SCLC	OR4F5 →	+0.013	+5.029	<.001	.006	3	1
LUNG_SCLC	OR13F1 →	+0.032	+5.029	<.001	.006	3	1
LUNG_SCLC	OR5H6 →	+0.025	+5.029	<.001	.006	3	1
LUNG_SCLC	OR5M1 →	+0.033	+5.029	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 17 associations by consensus.

IFNA14 by CRY1 expression — CNS

Explore this box plot interactively →