CRX

Across TCGA patient cohorts, CRX RNA expression is significantly associated with the go_rna of many other GO terms, with 6,761 significant associations in total. STAD shows the largest number of these associations.

The most reproducible CRX-associated GO terms across cancer lineages are Regulation of DNA repair, Nucleoside phosphate biosynthetic process, and Regulation of double-strand break repair. Each is linked with CRX in more than 15 cancer types. Because this analysis shows association rather than direction, both CRX-to-partner and partner-to-CRX results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of DNA repair grouped by CRX-low versus CRX-high in STAD.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CRX→partner) and Y-score (partner→CRX) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	Regulation of DNA repair →	+0.066	+0.275	<.001	<.001	3	16
STAD	Nucleoside phosphate biosynthetic process →	+0.060	+0.265	<.001	<.001	3	15
STAD	Regulation of double-strand break repair →	+0.065	+0.283	<.001	<.001	3	15
STAD	Protein localization to mitochondrion →	+0.066	+0.279	<.001	<.001	3	15
SCLC	Telomere organization →	+0.088	+0.479	<.001	<.001	2	16
STAD	ATP synthesis coupled electron transport →	+0.077	+0.293	<.001	<.001	3	15

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,761 associations by consensus.

Regulation of DNA repair by CRX expression — STAD

Explore this box plot interactively →