CRX

Across TCGA cell cohorts, CRX mutation is significantly associated with the RNA expression of many other genes, with 13 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible CRX-associated genes across cancer lineages are H2BW1, HCN4, and CYP11B1. Each is linked with CRX in more than 1 cancer types. Because this analysis shows association rather than direction, both CRX-to-partner and partner-to-CRX results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, H2BW1 grouped by CRX-low versus CRX-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CRX→partner) and Y-score (partner→CRX) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	H2BW1 →	+0.060	+3.874	.001	.005	3	1
BLOOD_Leukemia	HCN4 →	+0.040	+3.855	.001	.007	3	1
BLOOD_Leukemia	CYP11B1 →	+0.093	+4.234	<.001	.003	3	1
BLOOD_Leukemia	OR2Z1 →	+0.035	+4.060	<.001	.003	3	1
BLOOD_Leukemia	TSSK1B →	+0.009	+3.874	<.001	.005	3	1
UPPER_AERODIGESTIVE_TRACT	MMD2 →	+0.036	+4.736	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 13 associations by consensus.

H2BW1 by CRX expression — BLOOD_Leukemia

Explore this box plot interactively →