CRTC3

Across TCGA patient cohorts, CRTC3 mutation is significantly associated with the total protein of many other genes, with 16 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CRTC3-associated genes across cancer lineages are RAD51, HER3, and EGFR_pY1068. Each is linked with CRTC3 in more than 1 cancer types. Because this analysis shows association rather than direction, both CRTC3-to-partner and partner-to-CRTC3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RAD51 grouped by CRTC3-low versus CRTC3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CRTC3→partner) and Y-score (partner→CRTC3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RAD51 →	+0.140	+2.459	.015	.019	3	2
SKCM	HER3 →	+0.526	+2.824	.036	.036	3	1
UCEC	EGFR_pY1068 →	-0.252	-3.459	.014	.005	3	1
UCEC	ERK2 →	+0.220	+2.584	.005	.010	2	2
UCEC	INPP4B →	-0.273	-2.700	.040	.005	3	1
UCEC	MEK1 →	+0.466	+2.700	.002	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

RAD51 by CRTC3 expression — UCEC

Explore this box plot interactively →