CRTC3

Across TCGA cell cohorts, CRTC3 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,737 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible CRTC3-associated GO terms across cancer lineages are Promoter clearance during DNA-templated transcription, RNA polymerase II promoter clearance, and Mitotic cytokinesis. Each is linked with CRTC3 in more than 13 cancer types. Because this analysis shows association rather than direction, both CRTC3-to-partner and partner-to-CRTC3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Promoter clearance during DNA-templated transcription grouped by CRTC3-low versus CRTC3-high in KIDNEY.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CRTC3→partner) and Y-score (partner→CRTC3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	Promoter clearance during DNA-templated transcription →	+0.139	+0.948	.009	.008	3	14
KIDNEY	RNA polymerase II promoter clearance →	+0.139	+0.948	.009	.008	3	14
UPPER_AERODIGESTIVE_TRACT	Mitotic cytokinesis →	+0.072	+0.769	<.001	<.001	3	14
BONE	Microtubule nucleation →	+0.118	+0.831	<.001	<.001	3	14
STOMACH	Cytosolic transport →	+0.087	+1.087	.002	.001	3	13
BONE	Negative regulation of DNA-templated transcription initiation →	+0.120	+0.654	<.001	<.001	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,737 associations by consensus.

Promoter clearance during DNA-templated transcription by CRTC3 expression — KIDNEY

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