CRTC3

Across TCGA cell cohorts, CRTC3 mutation is significantly associated with the RNA expression of many other genes, with 13 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible CRTC3-associated genes across cancer lineages are ASPA, RNASE7, and OR4X2. Each is linked with CRTC3 in more than 1 cancer types. Because this analysis shows association rather than direction, both CRTC3-to-partner and partner-to-CRTC3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ASPA grouped by CRTC3-low versus CRTC3-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CRTC3→partner) and Y-score (partner→CRTC3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	ASPA →	+0.527	+3.781	<.001	.008	3	1
BLOOD_Lymphoma	RNASE7 →	+0.030	+3.754	.007	.008	3	1
BLOOD_Lymphoma	OR4X2 →	+0.061	+4.058	<.001	.009	3	1
BLOOD_Lymphoma	DEFB124 →	+0.128	+3.927	<.001	.004	3	1
BLOOD_Lymphoma	KRTAP9-2 →	+0.026	+4.662	<.001	.003	3	1
BLOOD_Lymphoma	GSTT4 →	+0.049	+3.821	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 13 associations by consensus.

ASPA by CRTC3 expression — BLOOD_Lymphoma

Explore this box plot interactively →