CRTC2

Across TCGA pan-cancer cohorts, CRTC2 mass-spec protein differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of CRTC2’s most consistent transcriptional readouts.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where CRTC2 mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types CRTC2 is over-expressed in tumor, although a few such as LSCC and LUAD show the opposite, repressed pattern.

CCRCC, LSCC, and LUAD are the cancer types where CRTC2 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CRTC2 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
CCRCC	Male	All	+0.238	<.001	9	view →
LSCC	Male	II,III,IV	−0.207	<.001	9	view →
LUAD	All	III,IV	−0.204	<.001	9	view →
PDAC	All	II,III,IV	−0.261	<.001	7	view →
OV	All	All	−0.393	.004	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

CRTC2–CCRCC

Open the CCRCC breakdown →