CRTC2

Across TCGA patient cohorts, CRTC2 mutation is significantly associated with the total protein of many other genes, with 8 significant associations in total. BLCA shows the largest number of these associations.

The most reproducible CRTC2-associated genes across cancer lineages are p38-MAPK_pT180_Y182, VHL, and YB-1. Each is linked with CRTC2 in more than 1 cancer types. Because this analysis shows association rather than direction, both CRTC2-to-partner and partner-to-CRTC2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p38-MAPK_pT180_Y182 grouped by CRTC2-low versus CRTC2-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CRTC2→partner) and Y-score (partner→CRTC2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	p38-MAPK_pT180_Y182 →	+0.404	+2.999	.043	.035	3	1
BLCA	VHL →	+0.949	+3.321	.018	.010	3	1
BLCA	YB-1 →	-0.195	-2.999	.029	.035	3	1
UCEC	JNK_pT183_Y185 →	-0.165	-3.000	.042	.036	3	1
UCEC	mTOR →	-0.196	-2.459	.012	.020	3	1
UCEC	4E-BP1_pT37_T46 →	-0.458	-2.459	.011	.020	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

p38-MAPK_pT180_Y182 by CRTC2 expression — BLCA

Explore this box plot interactively →