CRTC2

Across TCGA cell cohorts, CRTC2 mutation is significantly associated with the RNA expression of many other genes, with 14 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CRTC2-associated genes across cancer lineages are MAGEB5, SLITRK5, and HBQ1. Each is linked with CRTC2 in more than 1 cancer types. Because this analysis shows association rather than direction, both CRTC2-to-partner and partner-to-CRTC2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MAGEB5 grouped by CRTC2-low versus CRTC2-high in LUNG_NSCLC_LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CRTC2→partner) and Y-score (partner→CRTC2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	MAGEB5 →	+0.033	+4.643	<.001	.008	3	1
BLOOD_Lymphoma	SLITRK5 →	+0.719	+3.491	.003	.009	3	1
BLOOD_Lymphoma	HBQ1 →	+0.567	+3.762	.006	.004	3	1
BLOOD_Leukemia	IQCF5 →	+0.121	+5.201	<.001	.006	3	1
LARGE_INTESTINE	FMO1 →	+0.109	+3.921	<.001	.001	3	1
LARGE_INTESTINE	CILP →	+0.142	+3.443	.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

MAGEB5 by CRTC2 expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →