CRTC1

Across TCGA pan-cancer cohorts, CRTC1 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated CRTC1 data layer compared with 29 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher CRTC1 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated CRTC1 expression acts as an unfavorable survival marker, although some lineages such as LUAD and PDAC show a favorable association.

HNSC, LUAD, and PDAC are the cancer types where CRTC1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Tertile	All	0.595	0.885	.001	21	view →
LUAD	DFS	Median	All	0.745	0.426	.002	20	view →
PDAC	DFS	Quartile	All	0.921	0.620	<.001	13	view →
CCRCC	DFS	Quartile	II,III,IV	0.712	1.000	.010	13	view →
GBM	OS	Quartile	All	0.620	0.302	.001	10	view →
LSCC	DFS	Quartile	All	0.862	1.000	.012	6	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

CRTC1–HNSC (DFS)

Open the HNSC breakdown →